Small-molecule drugs taken by mouth that block specific molecular pathways driving cancer growth (kinases, PARP, CDK4/6, etc.).
Gilotrif · Afatinib
Boehringer Ingelheim Pharmaceuticals, Inc. Kinase Inhibitor [EPC] · Protein Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE GILOTRIF is a kinase inhibitor indicated for: First-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have non-resistant epidermal growth factor receptor (EGFR) mutations as d…
ALECENSA · Alectinib Hydrochloride
Genentech, Inc. From the FDA label: 1 INDICATIONS AND USAGE ALECENSA is a kinase inhibitor indicated for: adjuvant treatment in adult patients following tumor resection of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) (tumors ≥ 4 cm or node posi…
MEKTOVI · Binimetinib
Array BioPharma Inc. From the FDA label: 1 INDICATIONS AND USAGE MEKTOVI is a kinase inhibitor indicated: • in combination with encorafenib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved t…
Alunbrig · Brigatinib
Takeda Pharmaceuticals America, Inc. Kinase Inhibitor [EPC] · Tyrosine Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE ALUNBRIG is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test [see Dosage and Administratio…
TABRECTA · Capmatinib
Novartis Pharmaceuticals Corporation From the FDA label: 1 INDICATIONS AND USAGE TABRECTA is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as dete…
ZYKADIA · Ceritinib
Novartis Pharmaceuticals Corporation Kinase Inhibitor [EPC] · Tyrosine Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE ZYKADIA ® is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test [see Dosage…
Xalkori · Crizotinib
Pfizer Laboratories Div Pfizer Inc Kinase Inhibitor [EPC] · Cytochrome P450 3A Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE XALKORI is a kinase inhibitor indicated for the treatment of • adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FD…
Tafinlar · Dabrafenib
Novartis Pharmaceuticals Corporation From the FDA label: 1 INDICATIONS AND USAGE TAFINLAR is a kinase inhibitor indicated as a single agent for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test. ( 1.1 , 2.1 ) TAFINLAR i…
Vizimpro · Dacomitinib
Pfizer Laboratories Div Pfizer Inc From the FDA label: 1 INDICATIONS AND USAGE VIZIMPRO is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 L858R substitution mutations
BRAFTOVI · Encorafenib
Array BioPharma Inc. From the FDA label: 1 INDICATIONS AND USAGE BRAFTOVI is a kinase inhibitor indicated: Melanoma • in combination with binimetinib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-…
ENSACOVE · Ensartinib
Xcovery Holdings, Inc. From the FDA label: 1 INDICATIONS AND USAGE ENSACOVE is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive locally advanced or metastatic non-small cell lung cancer (NSCLC)as detected by an FDA-approved test [see Dosag…
Rozlytrek · Entrectinib
Genentech, Inc. From the FDA label: 1 INDICATIONS AND USAGE ROZLYTREK is a kinase inhibitor indicated for the treatment of: Adult patients with ROS1- positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test. ( 1.1 ) Adult and pediatric patien…
Erlotinib · Erlotinib
Aurobindo Pharma Limited From the FDA label: 1 INDICATIONS AND USAGE Erlotinib tablets are a kinase inhibitor indicated for: The treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon…
Erlotinib · Erlotinib Hydrochloride
Armas Pharmaceuticals Inc. From the FDA label: 1 INDICATIONS AND USAGE Erlotinib tablet is a kinase inhibitor indicated for: The treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 2…
Etoposide · Etoposide
BluePoint Laboratories Topoisomerase Inhibitor [EPC] · Topoisomerase Inhibitors [MoA]
From the FDA label: INDICATIONS AND USAGE Etoposide Injection is indicated in the management of the following neoplasms: Refractory Testicular Tumors Etoposide Injection in combination therapy with other approved chemotherapeutic agents in patients with refrac…
Gefitinib · Gefitinib
Qilu Pharmaceutical Co., Ltd. Kinase Inhibitor [EPC] · Protein Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE Gefitinib tablets are indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858…
LAZCLUZE · Lazertinib
Janssen Biotech, Inc. Kinase Inhibitor [EPC] · Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE LAZCLUZE, in combination with amivantamab, is indicated for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGF…
Lorbrena · Lorlatinib
U.S. Pharmaceuticals Kinase Inhibitor [EPC] · Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE LORBRENA ® is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test. LORBRENA
ZEPZELCA · Lurbinectedin
Jazz Pharmaceuticals, Inc. Alkylating Drug [EPC] · Alkylating Activity [MoA]
From the FDA label: 1 INDICATIONS AND USAGE ZEPZELCA is an alkylating drug indicated: • in combination with atezolizumab or atezolizumab and hyaluronidase-tqjs, for the maintenance treatment of adult patients with extensive-stage small cell lung cancer whose d…
TAGRISSO · Osimertinib
AstraZeneca Pharmaceuticals LP Kinase Inhibitor [EPC] · Kinase Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE TAGRISSO is a kinase inhibitor indicated for: • adjuvant therapy after tumor resection in adult patients with non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 delet…
Gavreto · Pralsetinib
Rigel Pharmaceuticals, Inc. Kinase Inhibitor [EPC] · Rearranged during Transfection (RET) Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE GAVRETO is a kinase inhibitor indicated for treatment of: Adult patients with metastatic rearranged during transfection (RET ) fusion-positive non-small cell lung cancer as detected by an FDA approved test (NSCLC). (…
CYRAMZA · Ramucirumab
Eli Lilly and Company Vascular Endothelial Growth Factor Receptor 2 Antagonist [EPC] · VEGFR2 Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE CYRAMZA ® is a human vascular endothelial growth factor receptor 2 (VEGFR2) antagonist indicated: as a single agent or in combination with paclitaxel, for treatment of adults with advanced or metastatic gastric or ga…
Augtyro · Repotrectinib
E.R. Squibb & Sons, L.L.C. Kinase Inhibitor [EPC] · Proto-Oncogene Tyrosine-Protein Kinase ROS1 Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE AUGTYRO is a kinase inhibitor indicated for the treatment of • adult patients with locally advanced or metastatic ROS1- positive non-small cell lung cancer (NSCLC). ( 1.1 ) • adult and pediatric patients 12 years of
RETEVMO · Selpercatinib
Eli Lilly and Company Kinase Inhibitor [EPC] · Rearranged during Transfection (RET) Inhibitors [MoA]
From the FDA label: 1 INDICATIONS AND USAGE RETEVMO ® is a kinase inhibitor indicated for the treatment of: Adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a rearranged during transfection (RET) gene fusion, as detect…
HYRNUO · Sevabertinib
Bayer HealthCare Pharmaceuticals Inc. From the FDA label: 1 INDICATIONS AND USAGE HYRNUO is indicated for the treatment of adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 ( ERBB2 ) tyrosine kinase domain (TKD) activating mut…
IBTROZI · Taletrectinib
Nuvation Bio Inc. From the FDA label: 1 INDICATIONS AND USAGE IBTROZI ® (taletrectinib) is indicated for the treatment of adult patients with locally advanced or metastatic ROS1 -positive non-small cell lung cancer (NSCLC) [see Dosage and Administration ( 2.1 )] . IBTROZI is a
TEPMETKO · Tepotinib Hydrochloride
EMD Serono, Inc. From the FDA label: 1 INDICATIONS AND USAGE TEPMETKO is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelial transition ( MET ) exon 14 skipping alterations. TEPMETKO is a kinase inhi…
Mekinist · Trametinib
Novartis Pharmaceuticals Corporation From the FDA label: 1 INDICATIONS AND USAGE MEKINIST is a kinase inhibitor indicated as a single agent for the treatment of BRAF-inhibitor treatment-naïve patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FD…
COSELA · Trilaciclib
G1 Therapeutics, Inc. From the FDA label: 1 INDICATIONS AND USAGE COSELA is indicated to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensiv…
HERNEXEOS · Zongertinib
Boehringer Ingelheim Pharmaceuticals, Inc. Kinase Inhibitor [EPC] · HER2/Neu/cerbB2 Antagonists [MoA]
From the FDA label: 1 INDICATIONS AND USAGE HERNEXEOS is indicated for the treatment of adult patients with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain activating mutations, a…