CancerDrs

Bladder Cancer clinical trials in Missouri

35 actively recruiting bladder cancer trials at 26 sites across Missouri.

Data from ClinicalTrials.gov · last refreshed

Payments from drug makers to the doctors running these trials

For 3 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll.

Phase 2, Phase 3 Recruiting NIH

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or urethra, but require an additional treatment called immunotherapy to help prevent their urinary tract (urothelial) cancer f…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT05987241
Sites in Missouri:
  • Saint Francis Medical Center — Cape Girardeau, Missouri
  • Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters, Missouri
  • MU Health - University Hospital/Ellis Fischel Cancer Center — Columbia, Missouri
  • Siteman Cancer Center at West County Hospital — Creve Coeur, Missouri
  • Parkland Health Center - Farmington — Farmington, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

This phase III trial compares the effect of decreased number of radiation (ultra-hypofractionated) treatments to the usual radiation number of treatments (hypofractionation) with standard of care chemotherapy, with cisplatin, gemcitabine o…

Sponsor: NRG Oncology
NCT ID: NCT07097142
Sites in Missouri:
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri
  • Mercy Cancer Center - Cape Girardeau — Cape Girardeau, Missouri
  • Saint Francis Medical Center — Cape Girardeau, Missouri
  • MU Health - University Hospital/Ellis Fischel Cancer Center — Columbia, Missouri
  • Parkland Health Center - Farmington — Farmington, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

The purpose of this study is to test a new medicine, vepugratinib, in comparison with placebo, to see if it is safe and can help people with a bladder cancer that is advanced or has spread. Vepugratinib or placebo will be administered in c…

Sponsor: Eli Lilly and Company
NCT ID: NCT07218380
Sites in Missouri:
  • Oncology Hematology Associates — Springfield, Missouri
  • Washington University School of Medicine — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

A phase 3b, Randomized, Controlled Trial of Nadofaragene Firadenovec vs. Observation in Participants with Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR NMIBC)

Sponsor: Ferring Pharmaceuticals
NCT ID: NCT06510374
Sites in Missouri:
  • Mercy Clinic Oncology and Hematology - David C. Pratt Cancer Center — Creve Coeur, Missouri
  • Specialty Clinical Research of St. Louis — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

The main purpose of this study is to compare the disease-free survival between participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of intermediate-risk NMIBC.

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT06319820
Sites in Missouri:
  • Mercy Research — St Louis, Missouri
  • Specialty Clinical Research of St Louis — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

This is a global, multicenter, randomized, open-label, Phase 2/3 study of Dato-DXd plus carboplatin or cisplatin versus gemcitabine plus carboplatin or cisplatin in participants with la/mUC who progressed during or after EV plus pembrolizu…

Sponsor: Daiichi Sankyo
NCT ID: NCT07129993
Sites in Missouri:
  • Research Site — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

Purpose: to assess efficacy and safety of Dato-DXd + rilvegostomig as adjuvant therapy versus SoC in MIUC participants with high-risk residual disease after radical resection. Study details: Duration: \~78 months (6.5 years) from FSI to la…

Sponsor: AstraZeneca
NCT ID: NCT07720284
Sites in Missouri:
  • Research Site — Kansas City, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)

This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together as a bladder preservation approach to treat patients with muscle invasive bladder cancer. The study will compare these drugs to concurr…

Sponsor: Astellas Pharma Global Development, Inc.
NCT ID: NCT07566156
Sites in Missouri:
  • Missouri Cancer Associates — Columbia, Missouri
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer

The goal of this clinical trial is to learn if TARA-002 can treat high-grade non-muscle invasive bladder cancer (NMIBC) in BCG-naïve adults 18 years of age or older. The main questions it aims to answer are: * Can the study drug help parti…

Sponsor: Protara Therapeutics
NCT ID: NCT07480356
Sites in Missouri:
  • Renown Regional Medical Center — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting NIH

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that has spread from where it first started (primary site) to other places in the…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT03866382
Sites in Missouri:
  • Mercy Oncology and Hematology - Clayton-Clarkson — Ballwin, Missouri
  • Central Care Cancer Center - Bolivar — Bolivar, Missouri
  • Parkland Health Center-Bonne Terre — Bonne Terre, Missouri
  • Cox Cancer Center Branson — Branson, Missouri
  • Mercy Cancer Center - Cape Girardeau — Cape Girardeau, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting NIH

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

This phase II trial tests the effect of giving pembrolizumab in combination with radiation therapy after chemotherapy in preventing surgery to remove the bladder in patients with muscle invasive bladder cancer. Standard of care therapy inc…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT07061964
Sites in Missouri:
  • Saint Francis Medical Center — Cape Girardeau, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting NIH

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

This phase II trial compares the use of pembrolizumab and radiation therapy to chemotherapy with cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C and radiation therapy for the treatment of non-muscle invasive bladder cancer. Immunothe…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT06770582
Sites in Missouri:
  • Saint Francis Medical Center — Cape Girardeau, Missouri
  • Parkland Health Center - Farmington — Farmington, Missouri
  • University of Kansas Cancer Center - Briarcliff — Kansas City, Missouri
  • University of Kansas Cancer Center - North — Kansas City, Missouri
  • University of Kansas Cancer Center - Lee's Summit — Lee's Summit, Missouri
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

This study is being done to learn more about a new medicine called PF-08634404. It is for adults with a type of bladder cancer called locally advanced or metastatic urothelial cancer (LA/mUC), meaning the cancer has spread to nearby tissue…

Sponsor: Pfizer
NCT ID: NCT07421700
Sites in Missouri:
  • Siteman Cancer Center - St. Peters — City of Saint Peters, Missouri
  • Siteman Cancer Center - West County — Creve Coeur, Missouri
  • Siteman Cancer Center - North County — Florissant, Missouri
  • Siteman Cancer Center — St Louis, Missouri
  • Barnes-Jewish Hospital — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

TARA-002-101-Ph2 is an open-label study to investigate the safety and efficacy of intravesical instillation of TARA-002 in adults 18 years of age or older with high-grade CIS NMIBC (± Ta/T1). The purpose of this Phase 2 study (TARA-002-101…

Sponsor: Protara Therapeutics
NCT ID: NCT05951179
Sites in Missouri:
  • Renown Regional Medical Center — St Louis, Missouri
  • Specialty Clinic Research of St. Louis — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

The purpose of the study in Part 1 (dose escalation) and in Part 2 (dose expansion) is to determine the recommended Phase 2 dose(s) (RP2D\[s\]) and evaluate preliminary clinical efficacy. Part 3 (dose expansion) will confirm safety and pre…

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT05316155
Sites in Missouri:
  • Specialty Clinical Research of St Louis — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

Researchers are looking for new ways to treat people with high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder but has not spread to the bladder muscle or outside of th…

Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06833073
Sites in Missouri:
  • University of Missouri Health Care ( Site 0126) — Columbia, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced unresectable or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma \[cutaneous/acral\], squamous cell carc…

Sponsor: Daiichi Sankyo
NCT ID: NCT06172478
Sites in Missouri:
  • Washington University, School of Medicine — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

This is a first in human, open-label, multi-center Phase 1 / 2 study to evaluate the safety, tolerability, and initial efficacy of AU-007, also known as imneskibart, in patients with advanced solid tumors. AU-007 will be administered eithe…

Sponsor: Aulos Bioscience, Inc.
NCT ID: NCT05267626
Sites in Missouri:
  • Washington University — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 2 Recruiting Federal

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary sympt…

Sponsor: White River Junction Veterans Affairs Medical Center
NCT ID: NCT05796375
Sites in Missouri:
  • VA St.Louis Healthcare System — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 1 Recruiting Industry

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers

TTX-080-001 is a Phase 1, open label, dose escalation and dose expansion clinical study to determine the safety, tolerability, and recommended Phase 2 dose of TTX-080 monotherapy (HLA-G inhibitor) and in combination with either pembrolizum…

Sponsor: Tizona Therapeutics, Inc
NCT ID: NCT04485013
Sites in Missouri:
  • Washington University in St Louis — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 1 Recruiting Industry

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435 may be used to treat cancer of the cel…

Sponsor: Eli Lilly and Company
NCT ID: NCT05614739
Sites in Missouri:
  • Washington University in St. Louis — St Louis, Missouri
View on ClinicalTrials.gov →
Phase 1 Recruiting Industry

A Phase 1/1b Study of IAM1363 in HER2 Cancers

This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.

Sponsor: Iambic Therapeutics, Inc
NCT ID: NCT06253871
Sites in Missouri:
  • Saint Luke's Cancer Institute — Kansas City, Missouri
  • Washington University School of Medicine — St Louis, Missouri
View on ClinicalTrials.gov →

Showing 25 of 35 trials with sites in Missouri. See all bladder cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-07-27