Brain Cancer clinical trials in Iowa

8 actively recruiting brain cancer trials at 15 sites across Iowa.

Data from ClinicalTrials.gov · last refreshed 2026-10-01

Phase 3 Recruiting Network

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are bei…

Sponsor: SWOG Cancer Research Network

NCT ID: NCT03418961

Sites in Iowa:

Medical Oncology and Hematology Associates-West Des Moines — Clive, Iowa
Mercy Cancer Center-West Lakes — Clive, Iowa
Alegent Health Mercy Hospital — Council Bluffs, Iowa
Greater Regional Medical Center — Creston, Iowa
Iowa Methodist Medical Center — Des Moines, Iowa

View on ClinicalTrials.gov →

Phase 3 Recruiting Network

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

This phase III trial tests two hypotheses in patients with low-risk and average-risk medulloblastoma. Medulloblastoma is a type of cancer that occurs in the back of the brain. The term, risk, refers to the chance of the cancer coming back …

Sponsor: Children's Oncology Group

NCT ID: NCT05382338

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 3 Recruiting Network

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while excluding…

Sponsor: Canadian Cancer Trials Group

NCT ID: NCT03550391

Sites in Iowa:

Iowa Methodist Medical Center — Des Moines, Iowa

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Phase 3 Recruiting Academic/Other

Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma

This phase III trial compares temporally-modulated pulsed radiation therapy versus standard radiation therapy in treating patients with newly diagnosed, IDH wildtype, MGMT-unmethylated glioblastoma. After completion of surgery, the standar…

Sponsor: NRG Oncology

NCT ID: NCT07452458

Sites in Iowa:

UI Health Care Mission Cancer and Blood - Ankeny Clinic — Ankeny, Iowa
Saint Anthony Regional Hospital — Carroll, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic — Clive, Iowa
Iowa Methodist Medical Center — Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic — Des Moines, Iowa

View on ClinicalTrials.gov →

Phase 2 Recruiting Network

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binime…

Sponsor: SWOG Cancer Research Network

NCT ID: NCT04511013

Sites in Iowa:

Mary Greeley Medical Center — Ames, Iowa
McFarland Clinic - Ames — Ames, Iowa
McFarland Clinic - Boone — Boone, Iowa
Saint Anthony Regional Hospital — Carroll, Iowa
Iowa Methodist Medical Center — Des Moines, Iowa

View on ClinicalTrials.gov →

Phase 2 Recruiting Network

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to …

Sponsor: Children's Oncology Group

NCT ID: NCT04684368

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting NIH

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or hig…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT05099003

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 1 Recruiting Academic/Other

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

Sitagliptin, when combined with standard-of-care drug bevacizumab, is being tested to 1) find out if it is effective at treating gliomas that have returned or progressed after treatment, and 2) find out what the highest dose of sitagliptin…

Sponsor: Kailin Yang, MD, PhD

NCT ID: NCT07541781

Sites in Iowa:

University of Iowa Health Care — Iowa City, Iowa

View on ClinicalTrials.gov →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-10-01