Brain Cancer clinical trials in Iowa

9 actively recruiting brain cancer trials at 7 sites across Iowa.

Data from ClinicalTrials.gov · last refreshed 2026-05-25

Phase 3 Recruiting Network

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are bei…

Sponsor: SWOG Cancer Research Network

NCT ID: NCT03418961

Sites in Iowa:

Medical Oncology and Hematology Associates-West Des Moines — Clive, Iowa
Mercy Cancer Center-West Lakes — Clive, Iowa
Alegent Health Mercy Hospital — Council Bluffs, Iowa
Greater Regional Medical Center — Creston, Iowa
Iowa Methodist Medical Center — Des Moines, Iowa

View on ClinicalTrials.gov →

Phase 3 Recruiting Academic/Other

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radia…

Sponsor: NRG Oncology

NCT ID: NCT06500455

Sites in Iowa:

Mary Greeley Medical Center — Ames, Iowa
McFarland Clinic - Ames — Ames, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 3 Recruiting Academic/Other

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer th…

Sponsor: NRG Oncology

NCT ID: NCT04804644

Sites in Iowa:

Mary Greeley Medical Center — Ames, Iowa
McFarland Clinic - Ames — Ames, Iowa

View on ClinicalTrials.gov →

Phase 3 Recruiting NIH

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT04166409

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 3 Recruiting Network

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

This phase III trial tests two hypotheses in patients with low-risk and average-risk medulloblastoma. Medulloblastoma is a type of cancer that occurs in the back of the brain. The term, risk, refers to the chance of the cancer coming back …

Sponsor: Children's Oncology Group

NCT ID: NCT05382338

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 2 Recruiting Network

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to …

Sponsor: Children's Oncology Group

NCT ID: NCT04684368

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting NIH

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or hig…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT05099003

Sites in Iowa:

Blank Children's Hospital — Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting Academic/Other

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

The goal of this interventional clinical trial is to provide proof-of-principle data for the biologic activity of defactinib in combination with avutometinib in brain metastases from melanoma, and to define the potential role of the combin…

Sponsor: University of Utah

NCT ID: NCT06194929

Sites in Iowa:

University of Iowa — Iowa City, Iowa

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Recruiting Industry

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinic…

Sponsor: Massive Bio, Inc.

NCT ID: NCT03452774

Sites in Iowa:

Massive Bio SYNERGY-AI site — Iowa City, Iowa

View on ClinicalTrials.gov →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-05-25