CancerDrs

Breast Cancer clinical trials in Pennsylvania

48 actively recruiting breast cancer trials at 69 sites across Pennsylvania.

Data from ClinicalTrials.gov · last refreshed

Payments from drug makers to the doctors running these trials

For 1 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll. See the full breast cancer transparency page →

Phase 3 Recruiting Academic/Other

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radi…

Sponsor: NRG Oncology
NCT ID: NCT04852887
Sites in Pennsylvania:
  • Saint Luke's Cancer Center - Allentown — Allentown, Pennsylvania
  • Saint Luke's University Hospital-Bethlehem Campus — Bethlehem, Pennsylvania
  • Crozer-Keystone Regional Cancer Center at Broomall — Broomall, Pennsylvania
  • Christiana Care Health System-Concord Health Center — Chadds Ford, Pennsylvania
  • Chambersburg Hospital — Chambersburg, Pennsylvania
Phase 3 Recruiting Academic/Other

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complet…

Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT06876714
Sites in Pennsylvania:
  • UPMC-Heritage Valley Health System Beaver — Beaver, Pennsylvania
  • UPMC Hillman Cancer Center at Butler Health System — Butler, Pennsylvania
  • Christiana Care Health System-Concord Health Center — Chadds Ford, Pennsylvania
  • WellSpan Medical Oncology and Hematology — Chambersburg, Pennsylvania
  • UPMC Hillman Cancer Center - Passavant - Cranberry — Cranberry Township, Pennsylvania
Phase 3 Recruiting Academic/Other

The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

The purpose of this study is to generate evidence on an alternative dosing strategy for CDK4/6 inhibitors to help more patients with Metastatic Breast Cancer (MBC) (age ≥ 65 years) tolerate side effects and stay on treatment longer, to der…

Sponsor: American Society of Clinical Oncology
NCT ID: NCT06377852
Sites in Pennsylvania:
  • Penn Medicine - Lancaster General Hospital — Lancaster, Pennsylvania
  • Penn Medicine - Perelman Center for Advanced Medicine — Philadelphia, Pennsylvania
  • Penn Medicine - Pennsylvania Hospital — Philadelphia, Pennsylvania
  • Penn Medicine - Chester County Hospital — West Chester, Pennsylvania
Phase 3 Recruiting Industry

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

This is a Phase III, randomised, open-label, 3-arm, multicentre, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with investigator's choice chemotherapy in combination with pembrolizuma…

Sponsor: AstraZeneca
NCT ID: NCT06103864
Sites in Pennsylvania:
  • Research Site — York, Pennsylvania
Phase 3 Recruiting Industry

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, both in combination with the investigator's choice of a CDK4/6 inhibitor (palbociclib, ribo…

Sponsor: Hoffmann-La Roche
NCT ID: NCT06065748
Sites in Pennsylvania:
  • Alliance Cancer Specialists — Bensalem, Pennsylvania
  • Ann B. Barshinger Cancer Institute — Lancaster, Pennsylvania
  • Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit — Philadelphia, Pennsylvania
  • WellSpan Oncology Research — York, Pennsylvania
Phase 3 Recruiting Industry

Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

A Phase Ib/III Open-label, Randomised Study of Capivasertib plus CDK4/6 Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced…

Sponsor: AstraZeneca
NCT ID: NCT04862663
Sites in Pennsylvania:
  • Research Site — Philadelphia, Pennsylvania
  • Research Site — Pittsburgh, Pennsylvania
  • Research Site — York, Pennsylvania
Phase 3 Recruiting Industry

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participant…

Sponsor: Hoffmann-La Roche
NCT ID: NCT06790693
Sites in Pennsylvania:
  • UPMC Hillman Cancer Center - Magee-Women?s Hospital — Pittsburgh, Pennsylvania
Phase 3 Recruiting Industry

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

This is a prospective, randomized, double-blinded, placebo-controlled, multi-center, Phase 3 study of GLSI-100 immunotherapy in HLA-A\*02 positive and HER2/neu positive subjects who are at high risk for disease recurrence and have complete…

Sponsor: Greenwich LifeSciences, Inc.
NCT ID: NCT05232916
Sites in Pennsylvania:
  • Redeemer Health - Holy Redeemer Hospital — Meadowbrook, Pennsylvania
  • Sidney Kimmel Comprehensive Cancer Center - Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
Phase 3 Recruiting Industry

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metasta…

Sponsor: Jazz Pharmaceuticals
NCT ID: NCT06435429
Sites in Pennsylvania:
  • Abramson Cancer Center of The University of Pennsylvania — Philadelphia, Pennsylvania
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania
Phase 2, Phase 3 Recruiting Industry

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physician's choice (TPC) (paclitaxel, nab-pa…

Sponsor: Bristol-Myers Squibb
NCT ID: NCT06926868
Sites in Pennsylvania:
  • Lehigh Valley Health Network — Allentown, Pennsylvania
  • Abramson Cancer Center of The University of Pennsylvania — Philadelphia, Pennsylvania
  • Local Institution - 0360 — Pittsburgh, Pennsylvania
Phase 3 Recruiting Industry

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

This phase 3 clinical trial compares the efficacy and safety of palazestrant with ribociclib to letrozole and ribociclib in women and men who have not received prior systemic anti-cancer treatment for advanced breast cancer.

Sponsor: Olema Pharmaceuticals, Inc.
NCT ID: NCT07085767
Sites in Pennsylvania:
  • Clinical Trial Site — Horsham, Pennsylvania
  • Clinical Trial Site — Sayre, Pennsylvania
Phase 2 Recruiting NIH

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally adva…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT05564377
Sites in Pennsylvania:
  • Lehigh Valley Hospital-Cedar Crest — Allentown, Pennsylvania
  • UPMC Altoona — Altoona, Pennsylvania
  • Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania
  • Bryn Mawr Hospital — Bryn Mawr, Pennsylvania
  • Pocono Medical Center — East Stroudsburg, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

The purpose of this clinical study is to learn about the safety and effects of the study medicine (called disitamab vedotin) for the possible treatment of people with breast cancer that is hard to treat and has spread in the body (advanced…

Sponsor: Pfizer
NCT ID: NCT06966453
Sites in Pennsylvania:
  • Alliance Cancer Specialists, PC — Bensalem, Pennsylvania
  • Alliance Cancer Specialists, PC — Doylestown, Pennsylvania
  • Alliance Cancer Specialists, PC — Horsham, Pennsylvania
  • Alliance Cancer Specialists, PC — Langhorne, Pennsylvania
  • Alliance Cancer Specialists, PC — Media, Pennsylvania
Phase 2 Recruiting Academic/Other

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators o…

Sponsor: QuantumLeap Healthcare Collaborative
NCT ID: NCT01042379
Sites in Pennsylvania:
  • University of Pennsylvania (U Penn) — Philadelphia, Pennsylvania
  • University Pittsburgh Medical Center — Pittsburgh, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) o…

Sponsor: Genmab
NCT ID: NCT05579366
Sites in Pennsylvania:
  • USOR Alliance Cancer Specialist — Doylestown, Pennsylvania
  • Allegheny Health Network — Pittsburgh, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

This study is open to adults aged 18 years and older with different types of HER2+ cancer that has spread and cannot be removed by surgery. People can take part in this study if their tumours show HER2 aberrations and previous treatment wa…

Sponsor: Boehringer Ingelheim
NCT ID: NCT06324357
Sites in Pennsylvania:
  • Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

This is an umbrella study evaluating the efficacy and safety of multiple treatment combinations in participants with metastatic or inoperable locally advanced breast cancer. The study will be performed in two stages. During Stage 1, seven …

Sponsor: Hoffmann-La Roche
NCT ID: NCT03424005
Sites in Pennsylvania:
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
  • University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

The purpose of this study is to assess the safety of GDC-4198 alone and in combination with giredestrant and also the efficacy of GDC-4198 + giredestrant versus abemaciclib + giredestrant in participants with locally advanced or metastatic…

Sponsor: Genentech, Inc.
NCT ID: NCT07100106
Sites in Pennsylvania:
  • University of Pennsylvania - Abramson Cancer Center — Philadelphia, Pennsylvania
  • UPMC - Hillman Cancer Center — Pittsburgh, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible s…

Sponsor: 858 Therapeutics, Inc.
NCT ID: NCT06395519
Sites in Pennsylvania:
  • Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

This is a Phase Ib/II, open-label, multicenter, randomized umbrella study in participants with breast cancer. The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatmen…

Sponsor: Hoffmann-La Roche
NCT ID: NCT04802759
Sites in Pennsylvania:
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
  • University of Pittsburgh Cancer Institute — Pittsburgh, Pennsylvania
Phase 2 Recruiting Academic/Other

Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

This clinical trial is evaluating tucatinib in combination with Doxil in participants with human epidermal growth factor 2 positive (HER2+) locally advanced or metastatic breast cancer. The main goals of this study are to: * Learn how well…

Sponsor: SCRI Development Innovations, LLC
NCT ID: NCT05748834
Sites in Pennsylvania:
  • Alliance Cancer Specialists — Bensalem, Pennsylvania
Phase 2 Recruiting Academic/Other

Converting HR+ Breast Cancer Into an Individualized Vaccine

Newly diagnosed post-menopausal women with clinical stage II-III, HR+HER2- breast cancer are eligible to a randomized trial, concurrently open at five US academic institutions. Patients receiving 4 months of standard neoadjuvant hormonal t…

Sponsor: Weill Medical College of Cornell University
NCT ID: NCT03804944
Sites in Pennsylvania:
  • UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania
Phase 2 Recruiting Academic/Other

ETHAN - ET for Male BC

This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male breast cancer. The drugs used in this …

Sponsor: Jose Pablo Leone
NCT ID: NCT05501704
Sites in Pennsylvania:
  • University of Pennsylvania, Abramson Cancer Center — Philadelphia, Pennsylvania
  • University of Pittsburgh Cancer Institute — Pittsburgh, Pennsylvania
Phase 2 Recruiting Academic/Other

Circulating Tumor DNA

This is a single-arm, phase II study examining elacestrant in the adjuvant treatment of patients with ER+ breast cancer who test positive for circulating tumor DNA (ctDNA) during the screening period of the trial. Our trial will proceed in…

Sponsor: Yale University
NCT ID: NCT06923527
Sites in Pennsylvania:
  • UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania

Showing 25 of 48 trials with sites in Pennsylvania. See all breast cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-07-07