Phase 3 Recruiting Academic/Other
This phase III trial compares cetuximab to chemotherapy, carboplatin and paclitaxel, with intensity modulated radiation therapy for the treatment of patients with head and neck cancer that may have spread from where it first started to nea…
Sponsor: NRG Oncology
NCT ID: NCT07441681
Sites in Georgia: - Emory Proton Therapy Center — Atlanta, Georgia
- Emory University Hospital Midtown — Atlanta, Georgia
Phase 3 Recruiting Industry
The purpose of this study is to compare anti-tumor activity of amivantamab in addition to pembrolizumab and carboplatin versus pembrolizumab, 5-fluorouracil (FU), and platinum therapy (carboplatin or cisplatin) in participants with refract…
Sponsor: Janssen Research & Development, LLC
NCT ID: NCT07276399
Sites in Georgia: - Emory University — Atlanta, Georgia
- Central Georgia Cancer Care — Macon, Georgia
Phase 3 Recruiting Industry
Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body. Researchers want to …
Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT07216703
Sites in Georgia: - Winship Cancer Institute of Emory University ( Site 5005) — Atlanta, Georgia
- Nancy N. & J.C. Lewis Cancer and Research Pavillion - Research Department ( Site 6005) — Savannah, Georgia
Phase 3 Recruiting Industry
The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer. The primary hypothesis is …
Sponsor: AVEO Pharmaceuticals, Inc.
NCT ID: NCT06064877
Sites in Georgia: - Emory University — Atlanta, Georgia
Phase 2 Recruiting Network
This phase II trial studies how well radiation therapy with or without cisplatin works in treating patients with stage III-IVA squamous cell carcinoma of the head and neck who have undergone surgery. Radiation therapy uses high energy x-ra…
Sponsor: ECOG-ACRIN Cancer Research Group
NCT ID: NCT02734537
Sites in Georgia: - Emory University Hospital Midtown — Atlanta, Georgia
- Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia
Phase 2 Recruiting NIH
This phase II trial tests the addition of chemotherapy, with carboplatin and paclitaxel, or chemo-immunotherapy, with carboplatin, paclitaxel and cemiplimab to standard salvage surgery followed by post operative radiation therapy and cispl…
Sponsor: National Cancer Institute (NCI)
NCT ID: NCT07195734
Sites in Georgia: - Emory Proton Therapy Center — Atlanta, Georgia
- Emory University Hospital Midtown — Atlanta, Georgia
Phase 1, Phase 2 Recruiting Industry
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with adv…
Sponsor: Turning Point Therapeutics, Inc.
NCT ID: NCT03093116
Sites in Georgia: - University Cancer and Blood Center — Athens, Georgia
- Local Institution - 2134 — Columbus, Georgia
Phase 1, Phase 2 Recruiting Industry
This is a Phase 1/2, open-label, non-randomized, 4-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX 106 administered as a single agent or in combinatio…
Sponsor: Inhibrx Biosciences, Inc
NCT ID: NCT04198766
Sites in Georgia: - Winship Cancer Institute - Emory University — Atlanta, Georgia
Phase 1, Phase 2 Recruiting Industry
This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) o…
Sponsor: Genmab
NCT ID: NCT05579366
Sites in Georgia: - Augusta University Georgia Cancer Center — Augusta, Georgia
Phase 1, Phase 2 Recruiting Industry
This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy…
Sponsor: Avenzo Therapeutics, Inc.
NCT ID: NCT07038343
Sites in Georgia: - Avenzo Therapeutics Recruiting Site — Atlanta, Georgia
Phase 2 Recruiting Industry
This study is researching an experimental drug called fianlimab (also called REGN3767), combined with a medication called cemiplimab compared against cemiplimab combined with placebo (a placebo looks like a treatment but does not contain a…
Sponsor: Regeneron Pharmaceuticals
NCT ID: NCT06769698
Sites in Georgia: - Emory University School of Medicine — Atlanta, Georgia
Phase 1, Phase 2 Recruiting Industry
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1310 in subjects with advanced solid tumors.
Sponsor: DualityBio Inc.
NCT ID: NCT05785741
Sites in Georgia: - Research Site 111 — Atlanta, Georgia
Phase 2 Recruiting Industry
A Phase II, Multicenter, Open-Label Trial of DB-1311 in combination with BNT327 or DB-1305 in Participants with Advanced/Metastatic Solid Tumors
Sponsor: DualityBio Inc.
NCT ID: NCT06953089
Sites in Georgia: - USA10-0 — Atlanta, Georgia
Phase 2 Recruiting Academic/Other
This research is being done to see how safe and effective the use of the study drug Ado-trastuzumab (T) emtansine (DM1), T-DM1, and standard of care chemoradiation are when used together in treating HER2-positive salivary gland cancer. It …
Sponsor: Dana-Farber Cancer Institute
NCT ID: NCT04620187
Sites in Georgia: - Winship Cancer Institute, Emory University — Atlanta, Georgia
Phase 2 Recruiting NIH
This phase II trial compares the effectiveness of cemiplimab with CDX-1140 to cemiplimab without CDX-1140 prior to surgery in treating patients with stage III-IV head and neck cancer. Immunotherapy with monoclonal antibodies, such as cemip…
Sponsor: National Cancer Institute (NCI)
NCT ID: NCT06980038
Sites in Georgia: - Emory University Hospital Midtown — Atlanta, Georgia
Phase 2 Recruiting Academic/Other
This phase II trial tests how well lovastatin and pembrolizumab work in treating patients with head and neck cancer that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) …
Sponsor: Emory University
NCT ID: NCT06636734
Sites in Georgia: - Emory University Hospital Midtown — Atlanta, Georgia
- Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia
Phase 2 Recruiting Industry
Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with an annual incidence of approximately 700,000 cases. This study aims to evaluate the change in disease activity and optimal dose, and optimal dos…
Sponsor: AbbVie
NCT ID: NCT07744126
Sites in Georgia: - City of Hope - Atlanta /ID# 285268 — Newnan, Georgia
Phase 2 Recruiting Academic/Other
This phase II trial tests how well atezolizumab works in treating patients with human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma that is able to be removed with surgery (resectable). Immunotherapy with atezolizumab,…
Sponsor: Emory University
NCT ID: NCT06254911
Sites in Georgia: - Emory University Hospital Midtown — Atlanta, Georgia
Phase 1 Recruiting Industry
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-M07D1 in patients with HER2 expressing advanced tumors.
Sponsor: SystImmune Inc.
NCT ID: NCT06293898
Sites in Georgia: - Georgia Cancer Center at Augusta University — Augusta, Georgia
Phase 1 Recruiting Industry
The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.
Sponsor: Coherus Oncology, Inc.
NCT ID: NCT06657144
Sites in Georgia: - Winship Cancer Center - Emory University — Atlanta, Georgia
Phase 1 Recruiting Industry
This is a FIH study is to evaluate the safety, tolerability, PK, immunogenicity, and preliminary antitumor activity of XB010 as a single agent and in combination with pembrolizumab in subjects with locally advanced or metastatic solid tumo…
Sponsor: Exelixis
NCT ID: NCT06545331
Sites in Georgia: - Winship Cancer Institute — Atlanta, Georgia
EARLY Phase 1 Recruiting Academic/Other
This early phase I trial compares sodium fluoride F-18 (F-18 NaF) positron emission tomography (PET)/computed tomography (CT) to the standard of care imaging scan (and fludeoxyglucose F-18 \[F-18 FDG\] PET/CT) for assessing the effects rad…
Sponsor: Emory University
NCT ID: NCT06914999
Sites in Georgia: - Emory University Hospital Midtown — Atlanta, Georgia
Recruiting Academic/Other
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in th…
Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT05334069
Sites in Georgia: - Northeast Georgia Medical Center Braselton — Braselton, Georgia
- Atlanta VA Medical Center — Decatur, Georgia
- Northeast Georgia Medical Center-Gainesville — Gainesville, Georgia
- The Longstreet Clinic - Gainesville — Gainesville, Georgia
- Low Country Cancer Care — Savannah, Georgia
NA Recruiting Academic/Other
This clinical trial is being done to learn whether using the proactive, graduated dose modification algorithm for leucovorin, 5-fluorouracil (5-FU), and oxaliplatin (FOLFOX) (PAGODA) algorithm to guide chemotherapy dosing for the FOLFOX re…
Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT07283939
Sites in Georgia: - Northside Hospital — Atlanta, Georgia
- Tift Regional Medical Center — Tifton, Georgia
NA Recruiting Network
This is a randomized controlled trial to compare survival for patients who undergoe robotic assisted laparoscopy versus open hysterectomy and lymph node assessment for the treatment of early stage cervical cancer.
Sponsor: GOG Foundation
NCT ID: NCT04831580
Sites in Georgia: - Georgian Cancer Center at Augusta University — Augusta, Georgia
- Southeastern Regional Medical Center LLC — Newnan, Georgia