Phase 3 Recruiting NIH
This phase III trial compares the effect of bevacizumab in combination with carboplatin, paclitaxel and pembrolizumab to the usual treatments of carboplatin and paclitaxel with or without pembrolizumab in treating patients with stage III, …
Sponsor: National Cancer Institute (NCI)
NCT ID: NCT07198074
Sites in Nevada: - Women's Cancer Center of Nevada — Las Vegas, Nevada
Phase 3 Recruiting Industry
DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when compared to chemotherapy (carboplatin + paclitaxel) + pembrolizumab (Arm C), by assessment of progress…
Sponsor: AstraZeneca
NCT ID: NCT06989112
Sites in Nevada: - Research Site — Las Vegas, Nevada
Phase 3 Recruiting Academic/Other
This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial cancer. Stand…
Sponsor: NRG Oncology
NCT ID: NCT05646316
Sites in Nevada: - Women's Cancer Center of Nevada — Las Vegas, Nevada
Phase 3 Recruiting Industry
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent. * EC is a type of cancer that starts in the tissues inside the uterus (womb) * pMMR indicate…
Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06952504
Sites in Nevada: - The Center of Hope ( Site 5018) — Reno, Nevada
Phase 3 Recruiting Industry
This study is being conducted to assess whether the study medicine PF 08634404, given in combination with chemotherapy, improves outcomes compared with another medicine called pembrolizumab plus chemotherapy. Chemotherapy is a type of canc…
Sponsor: Pfizer
NCT ID: NCT07578649
Sites in Nevada: - The Center of Hope — Reno, Nevada
Phase 3 Recruiting Industry
The study is divided into two cohorts (Cohort 1 and Cohort 2), to which participants will be enrolled based on the amount of human epidermal growth factor receptor 2 (HER2) in their tumor sample. In Cohort 1, the main goal is to assess how…
Sponsor: BioNTech SE
NCT ID: NCT06340568
Sites in Nevada: - The Center of Hope Reno — Reno, Nevada
Phase 2, Phase 3 Recruiting Industry
This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy. The study will be conducted in 2 parts. Part…
Sponsor: Kartos Therapeutics, Inc.
NCT ID: NCT05797831
Sites in Nevada: - Women's Cancer Center of Nevada — Las Vegas, Nevada
Phase 2 Recruiting NIH
This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally adva…
Sponsor: National Cancer Institute (NCI)
NCT ID: NCT05564377
Sites in Nevada: - OptumCare Cancer Care at Charleston — Las Vegas, Nevada
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation — Las Vegas, Nevada
- Summerlin Hospital Medical Center — Las Vegas, Nevada
- OptumCare Cancer Care at Fort Apache — Las Vegas, Nevada
- Renown Regional Medical Center — Reno, Nevada
Phase 2 Recruiting NIH
This phase II trial tests whether the combination of nivolumab and ipilimumab is better than nivolumab alone to shrink tumors in patients with deficient mismatch repair system (dMMR) endometrial carcinoma that has come back after a period …
Sponsor: National Cancer Institute (NCI)
NCT ID: NCT05112601
Sites in Nevada: - Women's Cancer Center of Nevada — Las Vegas, Nevada
Phase 2 Recruiting Network
This protocol tests de-escalated adjuvant treatment in patients with POLE-mutated or p53wt/NSMP (p53 wildtype/no specific molecular profile) early-stage endometrial cancer (EC). Patients may be enrolled in one of two sub-studies * EN10.A/R…
Sponsor: Canadian Cancer Trials Group
NCT ID: NCT05640999
Sites in Nevada: - Womens Cancer Center of Nevada — Las Vegas, Nevada
Phase 1, Phase 2 Recruiting Industry
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Sponsor: DualityBio Inc.
NCT ID: NCT05150691
Sites in Nevada: - Women's Cancer Center of Nevada — Las Vegas, Nevada
Phase 1, Phase 2 Recruiting Industry
A Study of Emi-Le in Participants with Solid Tumors
Sponsor: Day One Biopharmaceuticals, Inc.
NCT ID: NCT05377996
Sites in Nevada: - Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada
Phase 2 Recruiting Industry
A Phase 2 Multi-center Open-label Trial of nab-Sirolimus in Combination with Letrozole in Advanced or Recurrent Endometrioid Endometrial Cancer
Sponsor: Aadi Bioscience, Inc.
NCT ID: NCT05997017
Sites in Nevada: - Women's Cancer Center of Nevada — Las Vegas, Nevada