CancerDrs

Lung Cancer clinical trials in Maryland

52 actively recruiting lung cancer trials at 23 sites across Maryland.

Data from ClinicalTrials.gov · last refreshed

Payments from drug makers to the doctors running these trials

For 1 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll. See the full lung cancer transparency page →

Phase 2, Phase 3 Recruiting Network

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protoco…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT03851445
Sites in Maryland:
  • Luminis Health Anne Arundel Medical Center — Annapolis, Maryland
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland
  • Greater Baltimore Medical Center — Baltimore, Maryland
  • Sinai Hospital of Baltimore — Baltimore, Maryland
  • Saint Agnes Hospital — Baltimore, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting NIH

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT04267848
Sites in Maryland:
  • Luminis Health Anne Arundel Medical Center — Annapolis, Maryland
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland
  • Greater Baltimore Medical Center — Baltimore, Maryland
  • Sinai Hospital of Baltimore — Baltimore, Maryland
  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute — Baltimore, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting NIH

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT04181060
Sites in Maryland:
  • Walter Reed National Military Medical Center — Bethesda, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy \[IGRT\] and chemotherapy followed by immunotherapy with durvalumab or target…

Sponsor: NRG Oncology
NCT ID: NCT05624996
Sites in Maryland:
  • Luminis Health Anne Arundel Medical Center — Annapolis, Maryland
  • Greater Baltimore Medical Center — Baltimore, Maryland
  • Sinai Hospital of Baltimore — Baltimore, Maryland
  • TidalHealth Richard A Henson Cancer Institute — Ocean Pines, Maryland
  • TidalHealth Peninsula Regional — Salisbury, Maryland
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting NIH

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

This phase II/III trial compares the effect of adding radiation therapy to the usual maintenance therapy with atezolizumab versus atezolizumab alone in patients who have already received atezolizumab plus chemotherapy for the treatment of …

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT04402788
Sites in Maryland:
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland
  • UM Upper Chesapeake Medical Center — Bel Air, Maryland
  • Central Maryland Radiation Oncology in Howard County — Columbia, Maryland
  • UM Baltimore Washington Medical Center/Tate Cancer Center — Glen Burnie, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting NIH

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizuma…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT06096844
Sites in Maryland:
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland
  • Sinai Hospital of Baltimore — Baltimore, Maryland
  • William E Kahlert Regional Cancer Center/Sinai Hospital — Westminster, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radia…

Sponsor: NRG Oncology
NCT ID: NCT06500455
Sites in Maryland:
  • Maryland Proton Treatment Center — Baltimore, Maryland
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland
  • Sinai Hospital of Baltimore — Baltimore, Maryland
  • UM Upper Chesapeake Medical Center — Bel Air, Maryland
  • Central Maryland Radiation Oncology in Howard County — Columbia, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Network

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastase…

Sponsor: Children's Oncology Group
NCT ID: NCT05235165
Sites in Maryland:
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland
  • Sinai Hospital of Baltimore — Baltimore, Maryland
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland
  • Walter Reed National Military Medical Center — Bethesda, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

The purpose of this study is to understand if PF-08046054 alone works well compared to standard-of-care docetaxel alone in participants with non-small cell lung cancer (NSCLC) with PD-L1 expression greater than or equal to 1% and had cance…

Sponsor: Pfizer
NCT ID: NCT07144280
Sites in Maryland:
  • Maryland Oncology Hematology, P.A. — Annapolis, Maryland
  • Maryland Oncology Hematology, P.A. — Bethesda, Maryland
  • Maryland Oncology Hematology, PA — Brandywine, Maryland
  • Maryland Oncology Hematology — Columbia, Maryland
  • Maryland Oncology Hematology P.A. — Germantown, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

Multicenter, randomized (2:1), open-label phase 3 study in HLA-A2 positive patients with squamous and non-squamous metastatic NSCLC with ICI secondary resistance. Patients will be randomized into 2 arms (randomization 2:1): experimental Ar…

Sponsor: OSE Immunotherapeutics
NCT ID: NCT06472245
Sites in Maryland:
  • Ascension Saint Agnes Hospital — Baltimore, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

The purpose of this study is to evaluate efficacy and safety of Dato-DXd in combination with rilvegostomig or rilvegostomig monotherapy compared with pembrolizumab monotherapy as a first line therapy in participants with locally advanced o…

Sponsor: AstraZeneca
NCT ID: NCT06357533
Sites in Maryland:
  • Research Site — Annapolis, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

This phase III trial compares proton craniospinal irradiation (pCSI) to involved-field radiation therapy (IFRT) for the treatment of breast or non-small cell lung cancer that has spread from where it first started to the cerebrospinal flui…

Sponsor: NRG Oncology
NCT ID: NCT06500481
Sites in Maryland:
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untr…

Sponsor: Mirati Therapeutics Inc.
NCT ID: NCT06875310
Sites in Maryland:
  • Local Institution - 0702 — Annapolis, Maryland
  • Maryland Oncology Hematology - Columbia — Columbia, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene a…

Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06623422
Sites in Maryland:
  • Maryland Oncology Hematology (MOH) ( Site 8102) — Rockville, Maryland
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC). This study includes two substudies (substudy A and substudy B) that will recruit participants according to his…

Sponsor: BioNTech SE
NCT ID: NCT06712316
Sites in Maryland:
  • Frederick Health Hospital- James M Stockman Cancer Institute — Frederick, Maryland
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

This study will assess the effect of Dato-DXd in combination with osimertinib or Dato-DXd monotherapy versus platinum-based doublet chemotherapy in terms of progression-free survival (PFS).

Sponsor: AstraZeneca
NCT ID: NCT06417814
Sites in Maryland:
  • Research Site — Baltimore, Maryland
  • Research Site — Bethesda, Maryland
View on ClinicalTrials.gov →
Phase 2 Recruiting Network

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

This phase II Lung-MAP treatment trial test the combination of targeted drugs (capmatinib, osimertinib, and/or ramucirumab) in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tis…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT05642572
Sites in Maryland:
  • Kaiser Permanente-Woodlawn Medical Center — Baltimore, Maryland
  • UPMC Western Maryland — Cumberland, Maryland
  • Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland
  • Kaiser Permanente - Largo Medical Center — Largo, Maryland
  • Kaiser Permanente Lutherville - Timonium Medical Center — Lutherville, Maryland
View on ClinicalTrials.gov →
Phase 2 Recruiting Network

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places i…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT06031688
Sites in Maryland:
  • Kaiser Permanente-Woodlawn Medical Center — Baltimore, Maryland
  • Kaiser Permanente-Gaithersburg Medical Center — Gaithersburg, Maryland
  • Kaiser Permanente - Largo Medical Center — Largo, Maryland
  • Kaiser Permanente Lutherville - Timonium Medical Center — Lutherville, Maryland
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

This study will compare the effectiveness of osimertinib alone with the combination of osimertinib and chemotherapy (carboplatin and pemetrexed) in people with metastatic lung cancer that has a change (mutation) in the gene EGFR. Osimertin…

Sponsor: Memorial Sloan Kettering Cancer Center
NCT ID: NCT04410796
Sites in Maryland:
  • John Hopkins Medical Center — Baltimore, Maryland
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

This is an open-label, multicenter Phase 2 study evaluating BMS-986504 in participants with advanced and/or metastatic solid tumors that have MTAP deletion. The study includes a monotherapy component and a combination component in which BM…

Sponsor: Bristol-Myers Squibb
NCT ID: NCT07492680
Sites in Maryland:
  • Johns Hopkins Hospital — Baltimore, Maryland
View on ClinicalTrials.gov →

Showing 25 of 52 trials with sites in Maryland. See all lung cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-08-17