CancerDrs

Lung Cancer clinical trials in Texas

124 actively recruiting lung cancer trials at 54 sites across Texas.

Data from ClinicalTrials.gov · last refreshed

Payments from drug makers to the doctors running these trials

For 3 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll. See the full lung cancer transparency page →

Phase 2, Phase 3 Recruiting Network

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protoco…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT03851445
Sites in Texas:
  • Hendrick Medical Center — Abilene, Texas
  • The Don and Sybil Harrington Cancer Center — Amarillo, Texas
  • Parkland Memorial Hospital — Dallas, Texas
  • UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas
  • UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Network

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel and ramucirumab alone in treating patients with non-small cell lung cancer that is stage IV or that …

Sponsor: SWOG Cancer Research Network
NCT ID: NCT06616584
Sites in Texas:
  • The Don and Sybil Harrington Cancer Center — Amarillo, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radia…

Sponsor: NRG Oncology
NCT ID: NCT06500455
Sites in Texas:
  • MD Anderson in The Woodlands — Conroe, Texas
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center — Houston, Texas
  • Memorial Hermann Texas Medical Center — Houston, Texas
  • UT MD Anderson Cancer Center — Houston, Texas
  • MD Anderson West Houston — Houston, Texas
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates fo…

Sponsor: Mirati Therapeutics Inc.
NCT ID: NCT04613596
Sites in Texas:
  • Local Institution - 007-554B — Abilene, Texas
  • Local Institution - 007-554G — Amarillo, Texas
  • Local Institution - 007-879-A — Arlington, Texas
  • Local Institution - 007-879-B — Arlington, Texas
  • Local Institution - 007-892-B — Austin, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

The purpose of this study is to understand if PF-08046054 alone works well compared to standard-of-care docetaxel alone in participants with non-small cell lung cancer (NSCLC) with PD-L1 expression greater than or equal to 1% and had cance…

Sponsor: Pfizer
NCT ID: NCT07144280
Sites in Texas:
  • Texas Oncology - West Texas — Abilene, Texas
  • Texas Oncology-Northeast Texas — Allen, Texas
  • The Center for Cancer and Blood Disorders — Arlington, Texas
  • Texas Oncology- Central South. — Austin, Texas
  • Texas Oncology Central South — Austin, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.

Sponsor: Summit Therapeutics
NCT ID: NCT06767514
Sites in Texas:
  • Clinical Study Site — Abilene, Texas
  • Clinical Study Site — Austin, Texas
  • Clinical Study Site — Dallas, Texas
  • Clinical Study Site — Fort Worth, Texas
  • Clinical Study Site — Houston, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if ol…

Sponsor: Eli Lilly and Company
NCT ID: NCT06890598
Sites in Texas:
  • The Center for Cancer and Blood Disorders — Fort Worth, Texas
  • Kelsey-Seybold Clinic — Houston, Texas
  • Houston Methodist Hospital — Houston, Texas
  • University of Texas MD Anderson Cancer Center — Houston, Texas
  • USO - Texas Oncology - San Antonio — San Antonio, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untr…

Sponsor: Mirati Therapeutics Inc.
NCT ID: NCT06875310
Sites in Texas:
  • Texas Oncology Sammons Cancer Center — Dallas, Texas
  • Local Institution - 0692 — Galveston, Texas
  • Local Institution - 0652 — Laredo, Texas
  • Texas Oncology - San Antonio — San Antonio, Texas
  • Texas Oncology - Northeast Texas — Tyler, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

The goal of this Phase 3 clinical trial is to study the safety and efficacy of the nextgen anti-CTLA-4 antibody, gotistobart (ONC-392/BNT316), in patients with metastatic non-small cell lung cancer who have disease progressed on anti-PD-1/…

Sponsor: OncoC4, Inc.
NCT ID: NCT05671510
Sites in Texas:
  • Texas Oncology - Baylor Charles A. Sammons Cancer Center (USOR) - 1140 — Dallas, Texas
  • Texas Oncology - Denison - 1139 — Denison, Texas
  • Oncology Consultants, P.A. - 1120 — Houston, Texas
  • Oncology and Hematology of South Texas - 1165 — Laredo, Texas
  • Texas Oncology - McAllen - 1132 — McAllen, Texas
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer

This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to adults with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing type of lung cancer that has …

Sponsor: Pfizer
NCT ID: NCT07226999
Sites in Texas:
  • Texas Oncology - DFW — Arlington, Texas
  • Texas Oncology - DFW — Arlington, Texas
  • Texas Oncology - Gulf Coast — Beaumont, Texas
  • Texas Oncology - DFW — Bedford, Texas
  • Texas Oncology - DFW — Dallas, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

This is a Phase III, randomised, double-blind, placebo-controlled, multicentre, international study assessing the efficacy and safety of durvalumab (MEDI4736) and domvanalimab (AB154) compared with durvalumab plus placebo in adults with lo…

Sponsor: AstraZeneca
NCT ID: NCT05211895
Sites in Texas:
  • Research Site — Fort Sam Houston, Texas
  • Research Site — Kingwood, Texas
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC). This study includes two substudies (substudy A and substudy B) that will recruit participants according to his…

Sponsor: BioNTech SE
NCT ID: NCT06712316
Sites in Texas:
  • Millennium Research and Clinical Development, LLC — Houston, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients with advance…

Sponsor: NovoCure GmbH
NCT ID: NCT06216301
Sites in Texas:
  • Old Parkland Hospital Hematology Oncology Clinic — Dallas, Texas
  • UT Southwestern Medical Center — Dallas, Texas
  • DHR Health Oncology Institute — Edinburg, Texas
  • Houston Methodist Cancer Center — Houston, Texas
  • Methodist Richardson Cancer Center — Richardson, Texas
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Sponsor: Bristol-Myers Squibb
NCT ID: NCT07100080
Sites in Texas:
  • Local Institution - 0025 — Houston, Texas
  • Local Institution - 0173 — San Antonio, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

Beamion LUNG-3 study evaluates whether zongertinib, an oral HER2-targeted treatment, can improve outcomes compared with standard adjuvant treatment in adults with completely resected Stage II-IIIB non-small cell lung cancer (NSCLC) whose t…

Sponsor: Boehringer Ingelheim
NCT ID: NCT07195695
Sites in Texas:
  • Hendrick Health — Abilene, Texas
  • The University of Texas MD Anderson Cancer Center — Houston, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

The primary objectives are to compare progression-free survival (PFS) and overall survival (OS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet ch…

Sponsor: Amgen
NCT ID: NCT05920356
Sites in Texas:
  • Oncology Consultants PA — Houston, Texas
  • University of Texas MD Anderson Cancer Center — Houston, Texas
  • US Oncology Research Investigational Products Center — Irving, Texas
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Non-Squamous Non-Small Cell Lung Cancer (NSCLC) remains a leading cause of cancer mortality worldwide, with poor survival prospects for metastatic disease. The purpose of this study is to evaluate the optimized dose, adverse events, and ef…

Sponsor: AbbVie
NCT ID: NCT06236438
Sites in Texas:
  • Renovatio clinical /ID# 262000 — El Paso, Texas
  • Houston Methodist Hospital /ID# 262722 — Houston, Texas
  • Texas Oncology - Plano East /ID# 264356 — Plano, Texas
  • Texas Oncology - San Antonio Medical Center - Research Drive /ID# 264311 — San Antonio, Texas
  • Renovatio Clinical /ID# 261999 — The Woodlands, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

This is a study evaluating the efficacy and safety of calderasib with pembrolizumab as first-line treatment in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) with identified Kirsten rat sarcoma viral on…

Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06345729
Sites in Texas:
  • Oncology Consultants P.A. ( Site 0113) — Houston, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study Comparing TAK-928 With Docetaxel in Adults With Non-Small Cell Lung Cancer

Lung cancer is one of the most common forms of cancer. One common type is non-small cell lung cancer (NSCLC). NSCLC happens when abnormal cells in the lungs grow too fast. This can stop the lungs from working normally. This study focuses o…

Sponsor: Takeda
NCT ID: NCT07217301
Sites in Texas:
  • The University of Texas M.D Anderson Cancer Center (MDACC) — Houston, Texas
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

REGN7508 in Adult Participants for Prevention of Cancer-Associated Thrombosis

This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on the prevention of Cancer-Associated Thrombosis (CAT) in participants. The aim of the study is to see how effective the study drug…

Sponsor: Regeneron Pharmaceuticals
NCT ID: NCT07410117
Sites in Texas:
  • El Paso Medical Research Institute (Medresearch Inc) — El Paso, Texas
View on ClinicalTrials.gov →
Phase 2 Recruiting Network

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

This phase II Lung-MAP treatment trial test the combination of targeted drugs (capmatinib, osimertinib, and/or ramucirumab) in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tis…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT05642572
Sites in Texas:
  • The Don and Sybil Harrington Cancer Center — Amarillo, Texas
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-smal…

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT06667076
Sites in Texas:
  • Texas Oncology South — Austin, Texas
  • Parkland Health and Hospital System — Dallas, Texas
  • Texas Oncology DFW — Dallas, Texas
  • UT Southwestern Medical Center — Dallas, Texas
  • Renovatio Clinical — El Paso, Texas
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

This trial will evaluate the efficacy and safety of various therapies in participants with Stage IB, IIA, IIB, IIIA, or selected IIIB resectable and untreated NSCLC tumors that meet protocol-specified biomarker criteria.

Sponsor: Genentech, Inc.
NCT ID: NCT04302025
Sites in Texas:
  • Kelsey Seybold Clnic — Houston, Texas
  • University of Texas MD Anderson Cancer Center — Houston, Texas
  • Baylor College of Medicine — Houston, Texas
  • Lumi Research — Kingwood, Texas
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) o…

Sponsor: Genmab
NCT ID: NCT05579366
Sites in Texas:
  • USOR Texas Oncology — Abilene, Texas
  • Texas Oncology - Central / South Texas — Austin, Texas
  • Mary Crowley Cancer Research — Dallas, Texas
  • USOR Texas Oncology — Fort Worth, Texas
  • Texas Oncology - Northeast TX — Tyler, Texas
View on ClinicalTrials.gov →

Showing 25 of 124 trials with sites in Texas. See all lung cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-07-27