CancerDrs

Colorectal Cancer clinical trials

300 actively recruiting colorectal cancer trials in the United States. Cancer of the colon or rectum. Trials span screening, adjuvant therapy, and metastatic disease.

Data from ClinicalTrials.gov · last refreshed · Colorectal Cancer stats on SEER

64
Phase 1
91
Phase 2
20
Phase 3
1
Phase 4
124
Other

Colorectal Cancer by the numbers (U.S.)

154,270
Estimated new cases (2025)
52,900
Estimated deaths (2025)
65.4%
5-year relative survival
66
Median age at diagnosis

Source: NCI SEER Cancer Stat Facts

Browse colorectal cancer trials by state

California 117 Texas 117 Florida 88 New York 85 Pennsylvania 63 Massachusetts 62 Michigan 61 Tennessee 60 Virginia 58 Ohio 57 Missouri 55 Colorado 45 Minnesota 45 Arizona 44 Illinois 44 Washington 44 Maryland 43 North Carolina 37 New Jersey 34 Utah 32 Georgia 31 Wisconsin 29 Oklahoma 26 Oregon 26 Connecticut 24 Indiana 24 Kansas 24 Nebraska 24 Louisiana 19 District of Columbia 18 Iowa 18 Kentucky 17 Arkansas 16 South Carolina 15 South Dakota 13 Alabama 11 Idaho 10 Montana 10 Nevada 10 New Mexico 10 North Dakota 10 Rhode Island 10 Delaware 9 Mississippi 9 West Virginia 8 New Hampshire 7 Alaska 6 Hawaii 6 Maine 6 Wyoming 5 Vermont 2

Top trials by phase + site coverage

Phase 2, Phase 3 Recruiting Academic/Other

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.

Sponsor: NRG Oncology
NCT ID: NCT05174169
Locations:
  • University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
  • Thomas Hospital — Fairhope, Alabama
  • Mobile Infirmary Medical Center — Mobile, Alabama

+ 1013 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Network

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

This phase III trial evaluates whether a web-based intervention called Current Together after Cancer (CTAC) works to increase the number of patients with surgically removed (resected) colorectal cancer who receive surveillance care that al…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT07018869
Locations:
  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska

+ 373 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study

This phase III trial compares total ablative therapy and usual systemic therapy to usual systemic therapy alone in treating patients with colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for …

Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT05673148
Locations:
  • Kingman Regional Medical Center — Kingman, Arizona
  • Mayo Clinic Hospital in Arizona — Phoenix, Arizona
  • Tower Cancer Research Foundation — Beverly Hills, California

+ 179 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also determine what side effects happen when participa…

Sponsor: Seagen, a wholly owned subsidiary of Pfizer
NCT ID: NCT05253651
Locations:
  • Palo Verde Hematology Oncology — Glendale, Arizona
  • Mayo Clinic Building - Phoenix — Phoenix, Arizona
  • Mayo Clinic Hospital — Phoenix, Arizona

+ 126 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

The purpose of this study is to learn more about a new medicine called PF-08634404, and how well it works in people with cancer of the colon or rectum (CRC)). The goal is to understand if the new study medicine, combined with chemotherapy …

Sponsor: Pfizer
NCT ID: NCT07222800
Locations:
  • Ironwood Cancer & Research Centers — Chandler, Arizona
  • Ironwood Cancer & Research Centers — Gilbert, Arizona
  • Ironwood Cancer & Research Centers — Glendale, Arizona

+ 106 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.

Sponsor: Incyte Corporation
NCT ID: NCT07284849
Locations:
  • Ironwood Cancer & Research Centers — Chandler, Arizona
  • The University of Arizona Cancer Center — Tucson, Arizona
  • Roche Tissue Diagnostics, Companion Diagnostics — Tucson, Arizona

+ 77 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxalipl…

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT06662786
Locations:
  • Banner MD Anderson Cancer Center — Gilbert, Arizona
  • St. Bernard's Medical Center — Jonesboro, Arkansas
  • Highlands Oncology Group — Springdale, Arkansas

+ 74 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fl…

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT06750094
Locations:
  • Ironwood Cancer and Research Center — Chandler, Arizona
  • Banner MD Anderson Cancer Center — Gilbert, Arizona
  • Arizona Oncology Associates PC NAHOA — Prescott, Arizona

+ 64 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Tr…

Sponsor: Summit Therapeutics
NCT ID: NCT07228832
Locations:
  • Clinical Study Site — Goodyear, Arizona
  • Clinical Study Site — Beverly Hills, California
  • Clinical Study Site — Beverly Hills, California

+ 55 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instab…

Sponsor: GlaxoSmithKline
NCT ID: NCT05855200
Locations:
  • GSK Investigational Site — Tucson, Arizona
  • GSK Investigational Site — Los Angeles, California
  • GSK Investigational Site — New Haven, Connecticut

+ 46 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

The purpose of this study is to evaluate the safety and efficacy of pumitamig in combination with chemotherapy versus bevacizumab in combination with chemotherapy in participants with previously untreated, unresectable, or metastatic color…

Sponsor: Bristol-Myers Squibb
NCT ID: NCT07221357
Locations:
  • Local Institution - 0428 — Tucson, Arizona
  • Local Institution - 0432 — Springdale, Arkansas
  • Local Institution - 0447 — La Jolla, California

+ 46 more sites in the U.S.

View on ClinicalTrials.gov →
Phase 3 Recruiting Network

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the li…

Sponsor: ECOG-ACRIN Cancer Research Group
NCT ID: NCT05863195
Locations:
  • University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
  • UCHealth University of Colorado Hospital — Aurora, Colorado
  • UM Sylvester Comprehensive Cancer Center at Aventura — Aventura, Florida

+ 36 more sites in the U.S.

View on ClinicalTrials.gov →

Showing 12 of 300 trials. See all on ClinicalTrials.gov

Before you contact a trial site

Trial eligibility criteria are specific and strict. Reading them carefully before calling a site saves time. These guides walk through what to look for.

How to read clinical trial eligibility →

Inclusion, exclusion, biomarker requirements, performance status, and prior-therapy rules.

 How to find a clinical trial →

Search strategy, matching services, and when to involve your oncologist.

 Clinical trial phases explained →

Phase 1 through 4, what each means for patients.

 Insurance coverage for clinical trials →

The ACA requires coverage of routine patient costs. How to appeal denials.

Medical disclaimer: Information on this page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-05-11