CancerDrs

Prostate Cancer clinical trials

300 actively recruiting prostate cancer trials in the United States. The most common cancer in men in the U.S. Trials test hormonal, radiation, surgical, and novel therapies across risk groups.

Data from ClinicalTrials.gov · last refreshed · Prostate Cancer stats on SEER

44
Phase 1
108
Phase 2
24
Phase 3
4
Phase 4
120
Other

Prostate Cancer by the numbers (U.S.)

313,780
Estimated new cases (2025)
35,770
Estimated deaths (2025)
97.9%
5-year relative survival
68
Median age at diagnosis

Source: NCI SEER Cancer Stat Facts

Browse prostate cancer trials by state

Top trials by phase + site coverage

Phase 3 Recruiting Network

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach is better o…

Sponsor: Canadian Cancer Trials Group
NCT ID: NCT06592924
Locations:
  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska

+ 371 more sites in the U.S.

Phase 3 Recruiting Network

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation ther…

Sponsor: ECOG-ACRIN Cancer Research Group
NCT ID: NCT04423211
Locations:
  • Anchorage Associates in Radiation Medicine — Anchorage, Alaska
  • Alaska Breast Care and Surgery LLC — Anchorage, Alaska
  • Alaska Oncology and Hematology LLC — Anchorage, Alaska

+ 339 more sites in the U.S.

Phase 3 Recruiting Network

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT03678025
Locations:
  • Banner MD Anderson Cancer Center — Gilbert, Arizona
  • Cancer Center at Saint Joseph's — Phoenix, Arizona
  • Mayo Clinic Hospital in Arizona — Phoenix, Arizona

+ 331 more sites in the U.S.

Phase 3 Recruiting Academic/Other

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

This randomized phase III trial examines whether lengthening the dosage interval in an adaptive manner for the prostate cancer drug lutetium 177 Lu PSMA RLT improves quality of life without decreasing lifespan when compared to the standard…

Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT07200830
Locations:
  • Providence Alaska Medical Center — Anchorage, Alaska
  • AIS Cancer Center at San Joaquin Community Hospital — Bakersfield, California
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California

+ 99 more sites in the U.S.

Phase 3 Recruiting Academic/Other

Vitamin D for Prostate Endocrine Therapy

This phase III trial tests whether high-dose vitamin D works in treating androgen-deprivation therapy (ADT)-induced bone loss in patients with prostate cancer who are undergoing androgen-deprivation therapy. Vitamins are substances that th…

Sponsor: University of Rochester
NCT ID: NCT05838716
Locations:
  • Helen F Graham Cancer Center — Newark, Delaware
  • Medical Oncology Hematology Consultants PA — Newark, Delaware
  • Carle at The Riverfront — Danville, Illinois

+ 48 more sites in the U.S.

Phase 3 Recruiting Network

Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation…

Sponsor: Canadian Cancer Trials Group
NCT ID: NCT06235697
Locations:
  • Kaiser Permanente-Deer Valley Medical Center — Antioch, California
  • Kaiser Permanente Dublin — Dublin, California
  • Kaiser Permanente-Fremont — Fremont, California

+ 43 more sites in the U.S.

Phase 3 Recruiting Industry

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

The purpose of the study is to demonstrate superiority of Saruparib (AZD5305) relative to placebo added to a standard radiation therapy (RT) + androgen deprivation therapy (ADT) regimen by assessment of metastases-free survival in particip…

Sponsor: AstraZeneca
NCT ID: NCT06952803
Locations:
  • Research Site — Phoenix, Arizona
  • Research Site — Tucson, Arizona
  • Research Site — La Jolla, California

+ 42 more sites in the U.S.

Phase 3 Recruiting Industry

Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer

This is a prospective, open-label Phase 3 study to evaluate copper Cu 64 PSMA I\&T injection for PET/CT imaging in patients with newly diagnosed unfavorable intermediate high-risk, high-risk or very high-risk prostate cancer.

Sponsor: Curium US LLC
NCT ID: NCT06235151
Locations:
  • Urology Centers of Alabama — Homewood, Alabama
  • Arkansas Urology — Little Rock, Arkansas
  • Providence Medical Foundation — Fullerton, California

+ 41 more sites in the U.S.

Phase 3 Recruiting Industry

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

This study will explore whether a combination of the investigational drug PF-06821497 and enzalutamide will work better than taking enzalutamide alone in participants with mCRPC who are ARSi or abiraterone naïve.

Sponsor: Pfizer
NCT ID: NCT06629779
Locations:
  • Ironwood Cancer & Research Centers — Chandler, Arizona
  • Ironwood Cancer & Research Centers — Gilbert, Arizona
  • Palo Verde Hematology Oncology — Glendale, Arizona

+ 41 more sites in the U.S.

Phase 3 Recruiting Industry

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

The purpose of this study is to evaluate the efficacy and safety of lutetium (177Lu) vipivotide tetraxetan (AAA617) in participants with oligometastatic prostate cancer (OMPC) progressing after definitive therapy to their primary tumor. Th…

Sponsor: Novartis Pharmaceuticals
NCT ID: NCT05939414
Locations:
  • Highlands Oncology Group — Fayetteville, Arkansas
  • VA Greater LA Healthcare System — Los Angeles, California
  • VA Palo Alto Health Care System — Palo Alto, California

+ 38 more sites in the U.S.

Phase 3 Recruiting Industry

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

The primary objective of this study is to compare overall survival (OS) in participants receiving xaluritamig plus abiraterone against investigator's choice (docetaxel, cabazitaxel, or abiraterone).

Sponsor: Amgen
NCT ID: NCT07213674
Locations:
  • City of Hope Cancer Center Phoenix — Goodyear, Arizona
  • City of Hope National Medical Center — Duarte, California
  • City of Hope Orange County Lennar Foundation Cancer Center — Duarte, California

+ 34 more sites in the U.S.

Phase 3 Recruiting Industry

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases.

Sponsor: Clarity Pharmaceuticals Ltd
NCT ID: NCT06056830
Locations:
  • University of Alabama Birmingham Hospital — Birmingham, Alabama
  • Mayo Clinic- Phoenix — Phoenix, Arizona
  • Arkansas Urology Research Center, LLC — Little Rock, Arkansas

+ 24 more sites in the U.S.

Showing 12 of 300 trials. See all on ClinicalTrials.gov

Before you contact a trial site

Trial eligibility criteria are specific and strict. Reading them carefully before calling a site saves time. These guides walk through what to look for.

Medical disclaimer: Information on this page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-07-27