CancerDrs

Prostate Cancer clinical trials in Pennsylvania

45 actively recruiting prostate cancer trials at 40 sites across Pennsylvania.

Data from ClinicalTrials.gov · last refreshed

Payments from drug makers to the doctors running these trials

For 2 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll. See the full prostate cancer transparency page →

Phase 3 Recruiting Academic/Other

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

This phase III trial compares stereotactic body radiation therapy (SBRT), (five treatments over two weeks using a higher dose per treatment) to usual radiation therapy (20 to 45 treatments over 4 to 9 weeks) for the treatment of high-risk …

Sponsor: NRG Oncology
NCT ID: NCT05946213
Sites in Pennsylvania:
  • UPMC-Heritage Valley Health System Beaver — Beaver, Pennsylvania
  • Carlisle Regional Cancer Center — Carlisle, Pennsylvania
  • Christiana Care Health System-Concord Health Center — Chadds Ford, Pennsylvania
  • Chambersburg Hospital — Chambersburg, Pennsylvania
  • Geisinger Medical Center — Danville, Pennsylvania
Phase 3 Recruiting Network

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach is better o…

Sponsor: Canadian Cancer Trials Group
NCT ID: NCT06592924
Sites in Pennsylvania:
  • Christiana Care Health System-Concord Health Center — Chadds Ford, Pennsylvania
  • Geisinger Medical Center — Danville, Pennsylvania
  • Geisinger Cancer Center Dickson City — Dickson City, Pennsylvania
  • Geisinger Medical Center-Cancer Center Hazleton — Hazleton, Pennsylvania
  • Geisinger Medical Oncology-Lewisburg — Lewisburg, Pennsylvania
Phase 3 Recruiting Academic/Other

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

This phase III trial compares the effect of adding docetaxel to hormonal therapy and apalutamide versus hormonal therapy and apalutamide alone in treating patients with prostate cancer that has spread from where it first started (primary s…

Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT06931340
Sites in Pennsylvania:
  • Saint Vincent Hospital — Erie, Pennsylvania
  • Jefferson Hospital — Jefferson Hills, Pennsylvania
  • Forbes Hospital — Monroeville, Pennsylvania
  • Allegheny Valley Hospital — Natrona Heights, Pennsylvania
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
Phase 3 Recruiting Network

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

This phase III trial compares the effect of adding carboplatin to the standard of care chemotherapy drug cabazitaxel versus cabazitaxel alone in treating prostate cancer that keeps growing even when the amount of testosterone in the body i…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT06470243
Sites in Pennsylvania:
  • Lehigh Valley Hospital-Cedar Crest — Allentown, Pennsylvania
  • Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania
  • Christiana Care Health System-Concord Health Center — Chadds Ford, Pennsylvania
  • Pocono Medical Center — East Stroudsburg, Pennsylvania
  • Lehigh Valley Hospital-Hazleton — Hazleton, Pennsylvania
Phase 3 Recruiting Industry

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to find out whether treatment with pasritamig and docetaxel prolongs radiographic progression free survival (rPFS) (the length of time from start of treatment until disease worsens as determined by scans or dea…

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT07225946
Sites in Pennsylvania:
  • Lehigh Valley Hospital — Allentown, Pennsylvania
  • MidLantic Urology — Bala-Cynwyd, Pennsylvania
  • Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania
  • University Of Pittsburgh Medical Center UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania
Phase 3 Recruiting Industry

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall survival (OS) i…

Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06136624
Sites in Pennsylvania:
  • AHN Allegheny General Hospital ( Site 0001) — Pittsburgh, Pennsylvania
Phase 3 Recruiting Network

Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation…

Sponsor: Canadian Cancer Trials Group
NCT ID: NCT06235697
Sites in Pennsylvania:
  • Saint Vincent Hospital — Erie, Pennsylvania
  • Jefferson Hospital — Jefferson Hills, Pennsylvania
  • Forbes Hospital — Monroeville, Pennsylvania
  • Allegheny General Hospital — Pittsburgh, Pennsylvania
  • West Penn Hospital — Pittsburgh, Pennsylvania
Phase 3 Recruiting Industry

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

The primary objective of this study is to compare overall survival (OS) in participants receiving xaluritamig plus abiraterone against investigator's choice (docetaxel, cabazitaxel, or abiraterone).

Sponsor: Amgen
NCT ID: NCT07213674
Sites in Pennsylvania:
  • University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
Phase 2, Phase 3 Recruiting Industry

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and progressed on or after \[177Lu\]Lu-PSMA ta…

Sponsor: Novartis Pharmaceuticals
NCT ID: NCT06780670
Sites in Pennsylvania:
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania
Phase 3 Recruiting Industry

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

The intention of the study is to demonstrate superiority of AZD2265 relative to standard of care treatments by assessment of radiographic progression-free survival (rPFS) and overall survival (OS) in participants with mCRPC.

Sponsor: AstraZeneca
NCT ID: NCT07611110
Sites in Pennsylvania:
  • Research Site — Pittsburgh, Pennsylvania
Phase 2, Phase 3 Recruiting Federal

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate cancer-free survival…

Sponsor: VA Office of Research and Development
NCT ID: NCT04787744
Sites in Pennsylvania:
  • Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C mutation. Th…

Sponsor: PMV Pharmaceuticals, Inc
NCT ID: NCT04585750
Sites in Pennsylvania:
  • Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania
  • University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
  • WellSpan York Cancer Center — York, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

The main purpose of this study is to determine the safety, tolerability (how the body reacts to the drug\[s\]) and effectiveness (ability to treat the cancer) of REGN5678 (Nezastomig) alone, or in combination with cemiplimab. The study has…

Sponsor: Regeneron Pharmaceuticals
NCT ID: NCT03972657
Sites in Pennsylvania:
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of DZR123 (Tulmimetostat, CPI-0209), both as monotherapy and in comb…

Sponsor: Novartis Pharmaceuticals
NCT ID: NCT04104776
Sites in Pennsylvania:
  • Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania
Phase 2 Recruiting Federal

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

This is an unblinded, randomized clinical study comparing the efficacy of DNA damaging chemotherapy using carboplatin, to standard of care therapy for patients who have metastatic castrate resistant prostate cancer. This trial will use ola…

Sponsor: VA Office of Research and Development
NCT ID: NCT04038502
Sites in Pennsylvania:
  • Philadelphia MultiService Center, Philadelphia, PA — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer

This study is researching an investigational drug called REGN4336 both alone or together with another investigational drug called REGN5678. The study is focused on participants with previously treated metastatic prostate cancer. The main p…

Sponsor: Regeneron Pharmaceuticals
NCT ID: NCT05125016
Sites in Pennsylvania:
  • Penn Medicine University of Pennsylvania Health System — Philadelphia, Pennsylvania
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible s…

Sponsor: 858 Therapeutics, Inc.
NCT ID: NCT06395519
Sites in Pennsylvania:
  • Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center — Philadelphia, Pennsylvania
Phase 2 Recruiting Industry

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

The investigators have used national VHA data to demonstrate real-world efficacy of abiraterone and enzalutamide in Veterans with mCRPC. In the real-world that is the VHA, the investigators have successfully estimated g values that accurat…

Sponsor: Sun Pharmaceutical Industries Limited
NCT ID: NCT05422911
Sites in Pennsylvania:
  • Corporal Michael J. Crescenz VA Medical Center — Philadelphia, Pennsylvania
Phase 2 Recruiting Academic/Other

A Study of Tarlatamab for People With Prostate Cancer

The researchers are doing this study to find out whether tarlatamab is an effective treatment for Delta-like Protein 3 (DLL3)-positive prostate cancer that has spread to other parts of your body (metastasized) and has either come back afte…

Sponsor: Memorial Sloan Kettering Cancer Center
NCT ID: NCT07111507
Sites in Pennsylvania:
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

The purpose of this substudy is to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd), given alone or with other treatments in participants with metastatic castration-resistant prostate cancer (mCRPC). The goals of this study …

Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06863272
Sites in Pennsylvania:
  • UPMC Hillman Cancer Center ( Site 0014) — Pittsburgh, Pennsylvania
Phase 1, Phase 2 Recruiting Industry

First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

This first-time-in-human study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, preliminary clinical activity, and establish the benefit/risk of GSK5471713 given as a monotherapy in mCRPC.

Sponsor: GlaxoSmithKline
NCT ID: NCT07332455
Sites in Pennsylvania:
  • GSK Investigational Site — Philadelphia, Pennsylvania
Phase 1, Phase 2 Recruiting Academic/Other

Safety and Efficacy of AGN-INM176 in Prostate Patients With Rising PSA

This Phase I/II open-label trial aims to evaluate the safety and efficacy of the herbal supplement INM176 in patients with a history of prostate cancer or low-risk disease under active surveillance. The study will determine the recommended…

Sponsor: Milton S. Hershey Medical Center
NCT ID: NCT06600698
Sites in Pennsylvania:
  • Penn State Cancer Institute — Hershey, Pennsylvania
Phase 1 Recruiting Industry

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

The overall aim of the trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of AMG 509 (monotherapy and in combination with abiraterone acetate and enzalutamide) and to evaluate preliminary efficacy. As of Protocol Amen…

Sponsor: Amgen
NCT ID: NCT04221542
Sites in Pennsylvania:
  • Thomas Jefferson University — Philadelphia, Pennsylvania
  • University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
Phase 1 Recruiting Industry

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

Medicines that reduce the amount of testosterone in the body are commonly used to treat prostate cancer. PRL-02 depot is a potential treatment for men with advanced prostate cancer. It is given by an injection into the muscle. Men with adv…

Sponsor: Astellas Pharma Global Development, Inc.
NCT ID: NCT04729114
Sites in Pennsylvania:
  • MidLantic Urology — Bala-Cynwyd, Pennsylvania

Showing 25 of 45 trials with sites in Pennsylvania. See all prostate cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-10-01